| Date | Home | Away | Result |
|---|---|---|---|
| 10/17/25 1:30 PM | Andorra CF | FC Granada | 0-0 |
| 10/18/25 9:15 AM | AD Ceuta FC | CD Mirandes | 2-0 |
| 10/18/25 11:30 AM | Real Saragossa | CyD Leonesa | 0-5 |
| 10/19/25 7:00 AM | CD Leganes | FC Malaga | 2-0 |
| 10/19/25 9:15 AM | CD Castellon | Albacete Balompie | 0-1 |
| 10/19/25 9:15 AM | Real Valladolid | Sporting Gijon | 2-3 |
| 10/19/25 11:30 AM | Racing Santander | Deportivo La Coruna | 2-1 |
| 10/19/25 11:30 AM | Cordoba CF | UD Almeria | 1-1 |
| 10/19/25 2:00 PM | UD Las Palmas | SD Eibar | 3-1 |
| 10/20/25 1:30 PM | FC Cadiz | Burgos CF | 1-3 |
| 11/5/25 1:00 PM | Real Sociedad B | SD Huesca | 2-0 |